NCT06203327

Atrophic Gastritis Predicts the Risk of Gastric Cancer

Atrophic Gastritis Predicts the Risk of Gastric Cancer: a Prospective Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,042 (estimated)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.

Conditions

• Atrophic Gastritis

Interventions

Type	Name	Description
OTHER	Esophagogastroscopy (OLGA 0-Ⅰ)	Surveillance endoscopies at years 3-5.
OTHER	Esophagogastroscopy (OLGA II)	Surveillance endoscopies at years 2-3.
OTHER	Esophagogastroscopy (OLGA III-IV)	Surveillance endoscopies every year.

Timeline

• Start date: 2023-12-15
• Primary completion: 2034-12-31
• Completion: 2034-12-31
• First posted: 2024-01-12
• Last updated: 2024-12-30

Locations

1 site across 1 country: China