NCT06199830

A Case-control Study on the Differentiation Between Cough Variant Asthma and Chronic Cough

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 645 (actual)
• Sponsor: The First Affiliated Hospital of Zhejiang Chinese Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

this study aimed to compare characters in pulmonary function of patients with cough variant asthma and chronic cough and establish a diagnostic model.

Detailed description

the investigators retrospectively collected information from patients with chronic cough who underwent pulmonary tests at the First Affiliated Hospital of Zhejiang Chinese Medical University from January 2019 to December 2019. Data of external test were also from the First Affiliated Hospital of Zhejiang Chinese Medical University, and time period was from January 2023 to April 2023.Pulmonary function test and methacholine challenge test was performed by professional technicians. Characters between patients with cough variant asthma and chronic cough were compared to establish a diagnostic model.

Conditions

• Asthma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	positive bronchial provocation test	Patients were asked to inhale gradually increasing doses of methacholine (0.9% saline, 0.078, 0.312, 1.125 and 2.504 mg), and FEV1 was measured after each inhalation. This test was stopped until a reducing in baseline FEV1 of 20%.

Timeline

• Start date: 2022-03-01
• Primary completion: 2023-05-20
• Completion: 2023-08-31
• First posted: 2024-01-10
• Last updated: 2024-10-15

Locations

1 site across 1 country: China