NCT06194955

The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function

The Effect of Glucose-dependent Insulinotropic Polypeptide (GIP), Glucagon-like Peptide-1 (GLP-1) and Glucagon-like Peptide-2 (GLP-2) in Individuals With Genetically Altered Receptor Function

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This project will characterize the physiological effect of the hormones, GIP-, GLP-1- and GLP-2 infusions in a group of individuals that are carriers of GIP-, GLP-1- and GLP-2 receptor gene variants, respectively.

Detailed description

Participants with mutations in their GLP-1- and GIP receptor will attend five randomized experimental days, A1, A2, B, C and D. On day A1 an oral glucose tolerance test (OGTT) will be performed, and on day A2, an intravenous isoglycaemic glucose infusion (IIGI) will be performed. On experimental day B and C, the study participants will receive GLP-1 and GIP hormones, respectively, under stable glucose infusions and on experimental day D, they will receive infusion of salt water (placebo) under stable glucose infusion. Participants with mutations in their GLP-2 receptor will attend three randomized experimental days, E, F and G. A mixed meal test (MMT) will be performed on day E, an infusion with GLP-2 during fasting blood glucose levels will be performed on day F, and infusion with salt water (placebo) during fasting blood glucose levels will be performed on day G. Additionally, a DXA scan and arginine test will be performed on all study participants.

Conditions

• Incretin Effect

Interventions

Type	Name	Description
DRUG	GIP(1-42)	Infusion
DRUG	GLP-1	Infusion
DRUG	GLP-2	Infusion
OTHER	Placebo	Saline

Timeline

• Start date: 2023-01-04
• Primary completion: 2027-12-01
• Completion: 2027-12-01
• First posted: 2024-01-08
• Last updated: 2024-05-07

Locations

1 site across 1 country: Denmark