NCT06193499

A Study on the Effect of High-concentrated Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This is a randomized double-blinded randomized comparison between injection of platelet rich plasma (PRP) and placebo for thumb basale osteoarthritis.

Detailed description

The aim of this study is to evaluate if high-concentration PRP injection decreases pain and disability in patients with thumb base osteoarthritis in the short-term and compare the effect to placebo.90 patients will be inlcuded (45+45). The primary outcome is pain on load (numerical rating scale) after 6 months. Patient-rated outcome measures, pinch grip and key pinch, range of motion of the CMC.1 joint will be assessed before treatment and at 3, 6 and months after the injection. Participants and assessors will be blinded.

Conditions

• Osteoarthritis Thumb

Interventions

Type	Name	Description
PROCEDURE	Platelet rich plasma (PRP)	Intra-articular injection of platelet rich plasma (PRP)
OTHER	Placebo	Intra-articular Saline injection (0,6-1ml)

Timeline

• Start date: 2024-01-17
• Primary completion: 2026-12-31
• Completion: 2027-06-30
• First posted: 2024-01-05
• Last updated: 2025-06-03

Locations

1 site across 1 country: Sweden