NCT06188832

Efficacy of Dietary Fiber Supplementation (Soloways) in Patients With Specific Genetic Polymorphisms

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (actual)
• Sponsor: S.LAB (SOLOWAYS) · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This randomized, double-blind, placebo-controlled trial assessed the impact of a dietary fiber supplement (glucomannan, inulin, and psyllium) on weight and metabolic parameters in individuals with obesity-related genetic polymorphisms (FTO, MC4R, LEP, LEPR). Participants were adults aged 18-65 with a BMI ≥ 25 and confirmed genetic predispositions. The study, involving 216 participants (108 per group), ran over 12 weeks with assessments at 0, 4, 8, and 12 weeks. Primary outcome was Body-weight change in %. The study aimed to clarify the role of fiber supplements in genetically predisposed obese individuals.

Conditions

• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	glucomannan, inulin, and psyllium	the subjects recieved fiber supplement containing glucomannan, inulin, and psyllium
OTHER	placebo	the subjects recieved placebo

Timeline

• Start date: 2022-03-02
• Primary completion: 2022-11-19
• Completion: 2023-01-18
• First posted: 2024-01-03
• Last updated: 2025-03-27

Locations

1 site across 1 country: Russia