NCT06185686

Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Assessing Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 16 (estimated)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 8 Years – 21 Years
• Healthy volunteers: Not accepted

Summary

With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.

Conditions

• Brain Tumor, Primary

Interventions

Type	Name	Description
OTHER	Cognitive testing	NIH Toolbox Cognitive Battery and the Novel Cognitive Measure (NCM)
DEVICE	Resting State MRI/Precision functional mapping	At baseline (before the end of radiation therapy) and approximately 12 months after the completion of radiation therapy.

Timeline

• Start date: 2024-07-10
• Primary completion: 2027-07-31
• Completion: 2027-07-31
• First posted: 2023-12-29
• Last updated: 2025-07-18

Locations

1 site across 1 country: United States