NCT06182501

Interference by Activated Protein C Resistance in the Determination of Protein S Activity

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 9,470 (estimated)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Protein S is an anticoagulant protein and a cofactor of protein C. It is recommended to explore it first by a functional (chronometric) technique by assessing its cofactor activity of activated protein C. Existing tests measure the prolongation of a coagulation time. These tests are all dependent on factor V, but some patients have mutations in factor V (including V Leiden) that make them resistant to activated protein C activity. It is suspected that these mutations lead to underestimations of protein S activity by chronometric technique.

Conditions

• Resistance to Activated Protein C in the Determination of Protein S Activity

Timeline

• Start date: 2022-07-01
• Primary completion: 2023-12-01
• Completion: 2023-12-01
• First posted: 2023-12-27
• Last updated: 2023-12-27

Locations

1 site across 1 country: France