NCT06181149

Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Arizona State University · Academic / Other
• Sex: All
• Age: 3 Years
• Healthy volunteers: Accepted

Summary

Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. This study will provide a strong foundation for developing neural and behavioral interventions for stuttering. Participants will be asked to name pictures, read words/sentences silently or aloud, and listen to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation while reading and speaking.

Conditions

• Healthy Subjects
• Stuttering, Developmental

Interventions

Type	Name	Description
BEHAVIORAL	Delaying speech initiation	This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use transcranial magnetic stimulation to induce a temporal misalignment between prediction and auditory feedback while participants produce speech.
BEHAVIORAL	Auditory errors and pre-speech auditory modulation	This intervention will examine the contributions of auditory errors to pre-speech auditory modulation. Participants will receive auditory perturbations while speaking, and we will collect their brain activities throughout the study.
BEHAVIORAL	Contributions of the speech premotor cortex to pre-speech auditory modulation	This intervention will examine the effects of stimulation of the left ventral premotor cortex on pre-speech auditory modulation. Participants will receive electrical stimulation while speaking.
BEHAVIORAL	Delaying auditory feedback	This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use delayed auditory feedback to induce a temporal misalignment between prediction and auditory feedback while participants produce speech.

Timeline

• Start date: 2024-01-01
• Primary completion: 2027-12-30
• Completion: 2027-12-30
• First posted: 2023-12-26
• Last updated: 2025-08-21

Locations

2 sites across 1 country: United States