NCT06179797

Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Augusta University · Academic / Other
• Sex: All
• Age: 56 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.

Detailed description

Objective: The objective of this early phase study is to evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in preparation for a subsequent larger efficacy trial. In addition, we will evaluate the tolerability and adherence to the treatment protocol. Aim: We aim to measure blood biomarkers in response to daily remote ischemic conditioning (RIC) using a dose escalation study design in 40 patients with age-related cerebral white matter hyperintensities on MRI. Hypothesis: We hypothesize that there will be a significant change in the biomarker levels in a dose dependent fashion.

Conditions

• Age-related Cerebral White Matter Changes
• Cognition Disorder

Interventions

Type	Name	Description
DEVICE	remote ischemic conditioning	suprasystolic BP sequential compression of both arms with blood pressure cuffs for 5 min on/off for 4 cycles.

Timeline

• Start date: 2020-08-15
• Primary completion: 2023-12-15
• Completion: 2023-12-15
• First posted: 2023-12-22
• Last updated: 2023-12-22

Locations

1 site across 1 country: United States