NCT06179056

Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 48 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 16 Years – 40 Years
• Healthy volunteers: Accepted

Summary

* To evaluate and compare the anti-biofilm activity of Salicylic acid, Isotretinoin, and N-acetylcysteine against C. acne . * To assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.

Detailed description

The study was carried out on 24 patients with acne vulgaris. They were recruited from the outpatient clinic of the Dermatology and Venereology and Andrology Department, Zagazig University Hospitals, Egypt. The degree of severity of lesions was determined by the global acne grading system (GAGS) Microbiological samples were collected from all patients for: 1. Isolation of C. acnes 2. Antibiotic susceptibility testing for C. acnes isolates aganist the most commonly used antibiotics in treatment of acne(Azithromycin and Doxycycline) in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine 3. Testing biofilm forming ability of C. acnes isolates in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine

Conditions

• Acne Vulgaris

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.	Microbiological samples were collected from all patients for: 1. Isolation of C. acnes 2. Antibiotic susceptibility testing for C. acnes isolates against the most commonly used antibiotics in the treatment of acne(Azithromycin and Doxycycline) in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine 3. Testing biofilm forming ability of C. acnes isolates in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine

Timeline

• Start date: 2023-03-01
• Primary completion: 2024-02-01
• Completion: 2024-02-01
• First posted: 2023-12-21
• Last updated: 2024-04-23

Locations

1 site across 1 country: Egypt