NCT06178315

EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis

Randomized Trial of EUS-guided Celiac Plexus Block vs. Sham for Palliation of Pain in Chronic Pancreatitis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 94 (estimated)
• Sponsor: Orlando Health, Inc. · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this randomized trial is to assess the efficacy of EUS-CPB in the alleviation of abdominal pain in patients with chronic pancreatitis.

Detailed description

Chronic pancreatitis is a complex fibroinflammatory disease arising from numerous etiological factors and a variety of clinical manifestations. Abdominal pain is the most debilitating complication and can result in significant morbidity and impact on quality of life. Endoscopic ultrasonography (EUS) has been increasingly utilized for celiac plexus block (EUS-CPB), whereby a steroid in combination with a local anesthetic agent are injected into the celiac plexus within the abdominal cavity. The aim of this randomized trial is to assess the efficacy of EUS-CPB in the alleviation of abdominal pain in patients with chronic pancreatitis.

Conditions

• Chronic Pancreatitis

Interventions

Type	Name	Description
PROCEDURE	EUS-guided celiac plexus block	Under EUS-guidance, celiac plexus block will be performed with injection of bupivacaine and triamcinolone into the area of celiac plexus.
PROCEDURE	Sham procedure	Celiac plexus will not be performed in this arm.

Timeline

• Start date: 2023-12-07
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2023-12-21
• Last updated: 2023-12-21

Locations

1 site across 1 country: United States