NCT06175832

PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study

PPOS and CFA for Elective Freeze-all Ovarian Stimulation Cycles: a Prospective Cross-over Study

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

P-CCROSS is a randomized, prospective monocentric phase 4 study with a crossover study design. The aim of the study is to compare patient satisfaction (by means of questionnaires) and treatment compliance with IVF treatment with CFA (corifollitropin alfa) and PPOS (Progestin-Primed Ovarian Stimulation) versus conventional IVF treatment with a recombinant FSH/GnRH antagonist. The study will also compare patients undergoing elective fertility preservation versus PGT-A (pre-implantation genetic testing for aneuploidy) patients.The study will have a crossover design so that patients will receive both forms of treatment. The investigators will also compare the endocrine profile and ovarian response of CFA/PPOS versus rFSH/GnRH ovarian stimulation cycles.

Conditions

• Ovarian Stimulation
• Quality of Life
• Preimplantation Genetic Testing
• Fertility Preservation

Interventions

Type	Name	Description
DRUG	Elonva®	Single injection
DRUG	Puregon®	Multiple injections
DRUG	Orgalutran®	Multiple injections
DRUG	Gonapeptyl®	Double injection
DRUG	Cerazette®	Oral tablet

Timeline

• Start date: 2025-01-27
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2023-12-19
• Last updated: 2025-12-26

Locations

1 site across 1 country: Belgium