NCT06174389

ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)

Physiological Changes Underlying the Weight Loss Plateau in Human

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.

Detailed description

Participants will be asked to enroll for 18-months. Each participant will complete 3 in-person study visits, then participate an a 6-month weight loss program delivered remotely. Some participants may be invited to complete 3 additional in-person visits. Study Visit activities include questionnaires, blood draws, brain MRIs, body measurement and dual energy x-ray absorptiometry (DXA) scan for body composition measurement, a breathing test, and biopsies of muscle and fat tissue. Each participant will be provided a fitness tracker and body weight scale to use throughout the study.

Conditions

• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Behavioral Weight Loss Program	Behavioral Weight Loss Program is a modified version of the Diabetes Prevention Program.

Timeline

• Start date: 2023-10-01
• Primary completion: 2027-07-31
• Completion: 2027-07-31
• First posted: 2023-12-18
• Last updated: 2025-08-29

Locations

2 sites across 1 country: United States