NCT06171269

Using MRI to Identify Areas to Receive Lower Doses of Radiation Treatment in Men With Prostate Cancerdose Mapping to Preserve Quality of Life

A Prospective Study of Lower Dose Radiation (LO-RADS) for Prostate Cancer Using MRI Dose Mapping to Preserve Quality of Life

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Chicago · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to gather information on the safety and effectiveness of using an imaging technique called magnetic resonance imaging (MRI) to decrease radiation dose to the uninvolved prostate (areas of the prostate that do not clearly have cancer cells) while increasing radiation dose to the nodules (hardened areas of the prostate that have cancer cells).

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
RADIATION	Radiation	Radiation to the prostate gland will be given daily (Mon-Friday) for 4 weeks.
RADIATION	MRI	The study doctor will use an MRI scan to take pictures of the prostate gland. These images of the prostate gland will let the study doctor know which areas of the prostate contain cancer cells that need to be targeted with higher doses of radiation and which uninvolved areas to target with lower doses of radiation.
OTHER	Androgen Deprivation Therapy	Treatment of treating physician choice will be given for 6-24 months.

Timeline

• Start date: 2024-01-05
• Primary completion: 2027-02-14
• Completion: 2028-10-20
• First posted: 2023-12-14
• Last updated: 2026-03-04

Locations

1 site across 1 country: United States