NCT06170905

Whey Protein Pre-load and Postprandial Glycemia in Pregnancy

Effect of Whey Protein on Postprandial Glucose Excursions in Pregnant Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Ulm · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This pilot study aims to investigate the intake of whey protein prior to carbohydrate intake as an approach to modulate postprandial glucose excursions during pregnancy.

Detailed description

Gestational diabetes (GDM) has transgenerational health consequences and increases the risk of type 2 diabetes mellitus in both mother and child. However, there is a lack of practical nutritional concepts for the prevention and treatment of GDM. This randomized controlled pilot study investigates whether the intake of a protein drink before carbohydrate intake lowers postprandial blood glucose levels of pregnant women. Therefore, two 75g oral glucose tolerance tests are performed in 20 pregnant women in a cross-over design, whereby a whey protein solution is drunk 30 minutes before one of the oral glucose tolerance tests (OGTT). If a clinically relevant effect on blood glucose levels is identified, this project can clarify whether the reduction in postprandial glycemia was caused by changes in the secretion of insulin and incretins.

Conditions

• Pregnancy
• Postprandial Glycemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Whey protein-preload OGTT	Intake of 25 g whey protein diluted in water 30 minutes prior to the start of a regular 75 g oral glucose tolerance test

Timeline

• Start date: 2024-02-01
• Primary completion: 2025-04-17
• Completion: 2025-10-22
• First posted: 2023-12-14
• Last updated: 2025-12-03

Locations

1 site across 1 country: Germany