NCT06167616

Infections and Latent Autoimmune Diabetes in Adults

Infections and Genetic Susceptibility in LADA and Type 2 Diabetes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5,048 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 35 Years
• Healthy volunteers: Accepted

Summary

Infections are proposed risk factors for type 1 diabetes in children. The investigators will examine whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults.

Detailed description

The investigators will use data from a population-based Swedish case-control study (ESTRID) with incident cases of LADA (n=597) and matched controls (n=2386). History of infectious disease are ascertained through national and regional patient registers. The investigators will estimate adjusted odds ratios (OR) with 95% CI for ≥1 respiratory (any/upper/lower), gastrointestinal, herpetic, other or any infectious disease episode, or separately, for 1 and ≥2 infectious disease episodes, within 0-1, 1-3, 3-5 and 5-10 years before LADA diagnosis/matching. Stratified analyses will be performed based on HLA risk genotypes and GADA levels.

Conditions

• Latent Autoimmune Diabetes in Adults
• Type 2 Diabetes

Timeline

• Start date: 2010-09-01
• Primary completion: 2019-10-31
• Completion: 2019-10-31
• First posted: 2023-12-12
• Last updated: 2023-12-12

Locations

1 site across 1 country: Sweden