NCT06167122

Treatment Protocol and Long-Term Outcomes in Craniofacial Fibrous Dysplasia

Long-term Follow-up and Treatment Protocol for Craniofacial Fibrous Dysplasia From 40-year Data at Chang Gung Memorial Hospital: A Retrospective Case Series

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13 (actual)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: —

Summary

Craniofacial fibrous dysplasia (CFD) is a nonneoplastic disease characterized by fibro-osseous lesions in the affected bones. Treatment is mainly surgical and is stratified based on four different anatomical zones. This study aimed to evaluate the long-term outcomes and refine the algorithm for CFD.

Detailed description

According to Chen et. al for the appropriate surgical management of FD the craniofacial skeleton can be divided into four zones according to the consideration of facial cosmesis, vital anatomical region and function preserving. The aim of the study was to evaluate the outcome of nearly 40 years long-term follow up cohort group and refine the algorithm of surgical intervention of FD under 4 zones classification.

Conditions

• Craniofacial Fibrous Dysplasia

Interventions

Type	Name	Description
PROCEDURE	Craniofacial reconstruction	Zone 1 lesions: radical excision and immediate reconstruction with bone grafts for fibrous dysplasia lesions. Zone 2 lesions: trimming \& recontouring. Zone 3 lesions: observation or conservative recontouring; optic nerve decompression performed when continuous deterioration of vision, and external auditory canal surgery performed when cholesteatoma/near total ear canal stenosis. Zone 4: observation or conservative recontouring; orthognathic surgery performed when malocclusion or midface retrusion noted.

Timeline

• Start date: 2020-03-01
• Primary completion: 2021-02-10
• Completion: 2021-03-14
• First posted: 2023-12-12
• Last updated: 2023-12-12

Locations

1 site across 1 country: Taiwan