NCT06166420

Home-based Cervical Cancer Screening Project

Offering Home-based Versus Hospital-based HPV Counseling and Testing for Cervical Cancer Screening in Rural West Region of Cameroon: a Randomised Cluster Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,079 (actual)
• Sponsor: Prof. Patrick Petignat · Academic / Other
• Sex: Female
• Age: 30 Years – 49 Years
• Healthy volunteers: Accepted

Summary

Cervical cancer is a public health problem in Cameroon.In 2020, the country had a crude incidence of 20.2 per 100 000 women for an incidence to mortality ratio of 0.65. As for now, the country does not have a national screening program to combat the disease. Only 6% of cameroonian women have once been screened for cervical cancer. In order to increase screening uptake so as to reach 70% recommended by the World Health Organization (WHO), a home-based cervical cancer screening approach is proposed. The objective of our study is to compare two recruitment strategies for cervical cancer screening in rural Cameroon.

Detailed description

In 2018, a 5 years cervical cancer screening project called: "Promoting Comprehensive Cervical Cancer Prevention and Better Women's Health in Low- and Medium Resource Settings in the Health District of Dschang" was launched in the West Region of Cameroon. The study aimed at screening 2000 women per year following screen-triage-treatment as recommended by WHO in a 3T approach: Test with HPV self-sampling test, Triage by visual assessement of the cervix with acetic acid and lugol (VIA/VILI), Treatment with thermal ablation. Despite sensitization using communication information channels, uptake of the screening was below the target. In order to increase uptake of the screening, this study proposes a home-based strategy using Community Health Workers (CHW). Community Health Workers (CHW) are lay members of the community who carry out health promotion activities after training. In a randomised controlled cluster trial, two recruitment strategies for cervical cancer screening will be compared: in one arm a team made up of a CHW and a nurse will do door-to-door sensitization and propose home-based HPV self-sampling test to eligible women and in the other arm CHW will do door-to-door sensitization and issue invitation cards to eligible women for hospital-based HPV self-sampling test. This study is nested in ongoing cervical cancer screening project. Primary objective: To compare completeness of full screening between two different recruitment strategies in rural area: counselling and home-based HPV self-sampling test versus counselling and hospital-based HPV self-sampling test. Secondary objectives: * To determine the proportion of women who will carry out an HPV self-sampling test in both strategies within 3 months of sensitization. * To determine the proportion of HPV positive women who will undergo VIA/VILI in both arms within 3 months. * To assess the acceptability of home self-sampling HPV test and perception of single versus 2 visits approaches. * To determine predictors of non-adherence to care-seeking for HPV positive women. * To determine the number of pre-cancers and/or cancers diagnosed in both arms and their treatment. * To calculate the economic cost of both strategies. Mixed method design, quantitative and qualitative informations will be collected.

Conditions

• Cervical Cancer

Interventions

Type	Name	Description
OTHER	Experimental	Counseling on cervical cancer screening followed by home-based HPV self-sampling test proposal.
OTHER	Active comparator	Counseling on cervical cancer screening followed invitation to screen at Dschang District Hospital.

Timeline

• Start date: 2023-03-27
• Primary completion: 2024-08-31
• Completion: 2024-08-31
• First posted: 2023-12-12
• Last updated: 2025-01-15

Locations

1 site across 1 country: Cameroon