NCT06166303

Number of Previous Cesarean Sections on the Results of Angiogenic Factors.

Effect of Number of Previous Cesarean Sections on the Results of Angiogenic Factors. A Descriptive, Prospective Study.

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 540 (estimated)
• Sponsor: Saint Thomas Hospital, Panama · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. Although the usefulness of angiogenic factors in these scenarios is known, little is known about the effects that other conditions might have on their serum levels, mainly those that have an effect on trophoblastic invasion, the process that initiates implantation of the pregnancy in the endometrium. The purpose of the present study is to assess the effect that a history of uterine surgery, such as caesarean section, might have on angiogenic factor scores in subjects with no history of a hypertensive disorder of pregnancy.

Conditions

• Cesarean Section

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	sFlt-1/PGIF	Index of sFlt-1/PGIF

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-01-30
• Completion: 2026-03-30
• First posted: 2023-12-12
• Last updated: 2025-08-26

Locations

1 site across 1 country: Panama