Trials / Recruiting
RecruitingNCT06166147
A Prospective Study of Liquid Biopsy for Pancreatic Cancer Early Detection
A Proof of Concept Study of Pancreatic Cancer Early Detection by cfDNA Assay
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 276 (estimated)
- Sponsor
- Fudan University · Academic / Other
- Sex
- All
- Age
- 40 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
This study is a multi-center, observational study aiming at developing a machine learning-based early detection model using prospectively collected liquid biopsy samples from clinically-annotated individuals.
Detailed description
Peripheral blood samples from participants with new diagnosis of pancreatic cancers will be collected to characterize the cancer-specific circulating signals by sequencing cell free DNA. A noninvasive test integrating machine learning algorithm will be trained and validated through a two-stage approach in recruited well-classified individuals, along with non-cancers without clinical diagnosis of cancer after routine medical screening. The performance of liquid biospy assays discovering cancer from non-cancer will be evaluated in participants with benign disease as well as average risk individuals.
Conditions
Timeline
- Start date
- 2023-12-18
- Primary completion
- 2026-10-31
- Completion
- 2027-03-31
- First posted
- 2023-12-12
- Last updated
- 2024-09-19
Locations
3 sites across 1 country: China
Source: ClinicalTrials.gov record NCT06166147. Inclusion in this directory is not an endorsement.