NCT06164925

Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: University of Tartu · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.

Detailed description

The main questions the study aims to answer are: * What is the most effective pre-GLIM screening approach? * Which of the simple, globally accessible muscle mass measurement methods works the best in the context of GLIM? * How does using simpler approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition and 1-year mortality? Participants will be/have: * asked questions about their recent food intake and possible non-volitional weight loss * assessed for malnutrition with SGA * weighed, and their height will be measured (if not already recorded) * their muscle mass measured with a measuring tape (mid-upper arm circumference and calf circumference) and bioelectrical impedance * their muscle function measured using hand grip strength * have their patient records looked at to extract their weight and height data (if present), diagnoses, routine blood test results, abdominal computed tomography (CT) scan (if present), dual-energy x-ray absorptiometry (DEXA) scan (if present), 1-year mortality and personal identification code for documentation (the latter will be deleted when the study period is over).

Conditions

• Malnutrition

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Nutrition screening and assessment	The patient is interviewed for changes in body weight in the last six months and food intake in the last two weeks. The investigator evaluates the patient's diet, symptoms related to their nutritional status, and functional capacity according to the Subjective Global Assessment (SGA). The SGA tool itself is completed by the researcher. Height and weight of the patient are measured, if not yet recorded, and BMI is calculated. The patient's muscle mass is measured using mid-upper arm circumference (MUAC), calf circumference (CC) and bioelectrical impedance (BIA), and their muscle function assessed using hand grip strength.

Timeline

• Start date: 2023-12-13
• Primary completion: 2025-03-31
• Completion: 2025-06-30
• First posted: 2023-12-11
• Last updated: 2025-03-28

Locations

1 site across 1 country: Estonia