NCT06161077

Voice Quality Analysis of Patients With Laryngotracheal Stenosis

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

The investigators previously demonstrated that voice changes are common in patients with Laryngotracheal Stenosis (LTS), and patients typically report an improvement in voice outcomes following endoscopic dilation. Recently, NIH based programs such as a Bridge to Artificial Intelligence (Bridge2AI) have highlighted the use of artificial intelligence to identify acoustic biomarkers of disease. Therefore, the investigators hypothesize that progression of LTS scar can be quantified using acoustic measurements and machine learning. The goal of this clinical trial is to remotely monitor patient voice quality in an effort to determine if regularly performed voice recordings can be used as a diagnostic tool in order to predict the need for dilation procedures. The investigators feel that successful use of remote voice recording technology with algorithmic analysis will improve patient quality of life.

Conditions

• Idiopathic Subglottic Tracheal Stenosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Voice Biomarker Screening Too	The investigators will develop a screening tool using voice that can predict disease severity in idiopathic subglottic stenosis

Timeline

• Start date: 2026-07-01
• Primary completion: 2028-07-01
• Completion: 2028-12-01
• First posted: 2023-12-07
• Last updated: 2025-08-06

Locations

1 site across 1 country: United States