NCT06160960

Influence of Pupillary Behavior During Eye Surgery on Morphological and Functional Outcome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Klinikum Klagenfurt am Wörthersee · Academic / Other
• Sex: All
• Age: 18 Years – 120 Years
• Healthy volunteers: Accepted

Summary

Pupillary movement during eye surgery can be a challenge for eye surgeons. Despite the risk of intraocular lens damage and malpositioning due to mechanical manipulation1, iris manipulation may lead to a significant elevation of cytokines in the aqueous humor and an increase of postoperative inflammation2, 3. Iris damage is also known to lead to an increase of prostaglandin production which will not only lead to an increase of inflammation but also has an impact on intraoperative miosis4. This leads to the assumption that postoperative inflammation can be related to intraoperative pupillary movements due to the same leading cause of an increase of inflammatory mediators. Tracking intraoperative pupillary movements might therefore be a helpful tool for the prediction of postoperative PCME and could have an impact on therapeutic decisions after surgery.

Conditions

• Cataract
• Corneal Disease
• Vitreous Disorder

Interventions

Type	Name	Description
OTHER	OCT Scan, Video of pupil movement, video of toric lens	A picture of the central macular area is taken, video of pupil movment, video of toric lens rotation.

Timeline

• Start date: 2017-10-09
• Primary completion: 2024-10-01
• Completion: 2024-10-01
• First posted: 2023-12-07
• Last updated: 2023-12-07

Locations

1 site across 1 country: Austria