NCT06159764

National Registry of Cardioneuroablation in Recurrent Reflex Syncope

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

This registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in France. The aim is to evaluate success rates, compare techniques and help institutions set up their own cardioneuroablation program

Detailed description

Cardioneuroablation is an emerging technique used to treat patients with vagally-mediated extrinsic bradycardia. It seems particularly efficient in patients with recurrent vasovagal syncope due to a strong cardioinhibitory effect. The procedure consists in using radiofrequency ablation to destroy cardiac ganglionated plexi located in epicardial fat pads around the atrias. Key questions concerning this procedure still remain unanswered: 1) What is the success rate of the procedure 2) Which patients will benefit from this technique? 3) Which fat pads should be targeted during the procedure? 4) What is the best way of identifying the location of these fat pads? 5) What are the long-term effects of this procedure? A multicenter registry seems ideal to try to answer these questions at minimal cost

Conditions

• Syncope, Vasovagal
• Bradycardia
• Heart Arrest

Interventions

Type	Name	Description
PROCEDURE	Cardioneuroablation	radiofrequency ablation to destroy cardiac ganglionated plexi located in epicardial fat pads around the atrias

Timeline

• Start date: 2024-11-27
• Primary completion: 2026-01-31
• Completion: 2026-01-31
• First posted: 2023-12-07
• Last updated: 2025-06-17

Locations

14 sites across 1 country: France