NCT06158217

Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Beijing Friendship Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. The cavitation effect of ultrasound-stimulated microbubbles (USMBs) is known to enhance tumor blood perfusion, so we conducted a prospective human study to investigate the effects of USMBs on hemoperfusion in invasive breast cancer (IBC).

Detailed description

patients with IBC were selected from the breast surgery department of our hospital. To induce an enhanced perfusion effect, IBC tumors were treated with SonoVue® microbubbles (MBs) stimulated by ultrasound, with a mechanical index (MI) of 0.2-0.3; 1 mL of SonoVue® MBs were injected at 3.5-min intervals three times for a USMB treatment lasting 10 min. The contrast-enhanced ultrasound (CEUS) parameters peak intensity (PI), area under the curve (AUC), and perfusion area were used to evaluate the changes in blood perfusion.

Conditions

• Invasive Breast Cancer
• Cavitation
• Perfusion

Interventions

Type	Name	Description
PROCEDURE	ultrasound combined with microbubbles	IBC tumors were treated with microbubbles (MBs) stimulated by ultrasound

Timeline

• Start date: 2022-09-29
• Primary completion: 2025-05-06
• Completion: 2025-05-06
• First posted: 2023-12-06
• Last updated: 2023-12-06

Locations

1 site across 1 country: China