NCT06156722

The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay May Improve ICSI Outcome.

The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay Improves ICSI Outcomes: A Randomized Prospective Sibling-oocytes Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 189 (actual)
• Sponsor: Meir Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years – 38 Years
• Healthy volunteers: Accepted

Summary

In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes. The methods include the selection of the optimal spermatozoa based on its morphology by IMSI, together with its physiological function of binding to HA by Spermslow (SS). The current study compared a group of ET after sperm selection by IMSI with SS to a group of ET after sperm selection by IMSI-only without SS, and to a mixed ET group where two embryos were transferred, one after IMSI-only and the other one after IMSI with SS.

Conditions

• Fertility Issues

Interventions

Type	Name	Description
PROCEDURE	Sperm selection by IMSI	Intracytoplasmic morphologically selected sperm injection (IMSI) is a sperm selection method used in intracytoplasmic sperm injection (ICSI)
PROCEDURE	Sperm selection by IMSI and spermslow	Intracytoplasmic morphologically selected sperm injection (IMSI) is a sperm selection method used in intracytoplasmic sperm injection (ICSI) + spermslow

Timeline

• Start date: 2019-03-01
• Primary completion: 2024-02-01
• Completion: 2024-02-01
• First posted: 2023-12-05
• Last updated: 2023-12-19

Locations

1 site across 1 country: Israel