NCT06155656

Effects of Pea Proteins With Different Degrees of Processing on Postprandial Metabolism in Healthy Adults

Acute Effects of Pea Proteins With Different Degrees of Processing on Postprandial Metabolism in Healthy Women and Men

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Bonn · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate the postprandial metabolic responses to plant-based protein ingredients of different degrees of processing (pea protein concentrate, isolate, and extrudate) and in comparison to whey protein in healthy adults. Therefore, young healthy subjects consume 4 test meals with 25 g of protein from pea protein concentrate, pea protein isolate, pea protein extrudate or whey protein in a randomized order. In a postprandial period of 6 hours, parameters of protein and glucose metabolism (i.a. plasma amino acids), gastric emptying and hunger/satiety are analysed. It is assumed that the plasma amino acid profile after plant protein ingestion differs depending on processing level of the protein ingredients and in comparison to whey protein.

Detailed description

In a randomized crossover-design, 20 healthy women and men consume 4 test meals containing either 25 g of protein from plant protein ingredients (pea protein concentrate, isolate, or extrudate) or whey protein together with 1 g paracetamol, which is used as a marker for gastric emptying. During a postprandial period of 6 hours parameters of protein metabolism (e.g. amino acids in plasma and urine), glucose metabolism (plasma glucose, serum insulin) and gastric emptying rate (based on plasma paracetamol) are analysed. Furthermore, subjective hunger/satiety and acceptance of the meals are assed using visual analogue scales. Each intervention arm will be separated by a washout period of at least 7 days.

Conditions

• Plasma Amino Acid Appearance and Disappearance
• Postprandial Metabolic Events

Interventions

Type	Name	Description
OTHER	Pea protein concentrate	Ingestion of a soup containing 25 g of protein from pea protein concentrate
OTHER	Pea protein isolate	Ingestion of a soup containing 25 g of protein from pea protein isolate
OTHER	Pea protein extrudate	Ingestion of a soup containing 25 g of protein from pea protein extrudate
OTHER	Whey protein	Ingestion of a soup containing 25 g of protein from whey protein

Timeline

• Start date: 2024-01-22
• Primary completion: 2024-06-28
• Completion: 2024-06-28
• First posted: 2023-12-04
• Last updated: 2025-04-23

Locations

1 site across 1 country: Germany