NCT06154083

INtensity of OVarian Stimualtion and Euploid Embryos

The Impact of Ovarian Stimulation Intensity on Embryo Euploidy in Advanced Age Women

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 110 (estimated)
• Sponsor: Fundación Santiago Dexeus Font · Academic / Other
• Sex: Female
• Age: 38 Years – 42 Years
• Healthy volunteers: Not accepted

Summary

This randomized trial was designed as a no-inferiority trial aiming to evaluate if the intensity of stimulation (a milder vs a more intense approach) may have an impact on the number of euploid embryos and the morpho kinetic parameters in advanced age women undergoing PGT-A with a PPOS protocol.

Conditions

• Fertility

Interventions

Type	Name	Description
DRUG	Follitropin-delta (Rekovelle) 20 mcg/day from D1	On day 2 or 3 of the menstrual cycle, daily injections of 20 mcg of Rekovelle (Stimulation Day 1) will be administered. Scan controls blood exams are performed on stimulation days 6, 8, 10 and, according to clinical needs, until trigger day. The dose will be the same during the whole course of stimulation and no dose adjustments will be performed.
DRUG	Follitropin-delta (Rekovelle) 15 mcg/day from D1	On day 2 or 3 of the menstrual cycle, daily injections of 15 mcg of Rekovelle (Stimulation Day 1) will be administered. Scan controls and blood exams are performed on stimulation days 6, 8, 10 and, according to clinical needs, until trigger day. The dose will be the same during the whole course of stimulation and no dose adjustments will be performed.

Timeline

• Start date: 2023-12-12
• Primary completion: 2025-12-15
• Completion: 2026-05-15
• First posted: 2023-12-01
• Last updated: 2025-02-27

Locations

1 site across 1 country: Spain