NCT06153602

Effectiveness of Nalbuphine as an Adjuvant to Subarachnoid Block on Postoperative Analgesia in TURP Surgery

Effectiveness of Intrathecal Nalbuphine as an Adjuvant to Subarachnoid Block on Postoperative Analgesia in Patients Undergoing Transurethral Resection of the Prostate

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Chulalongkorn University · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to compare pain after surgery in patients undergoing Transurethral Resection of Prostate. The main question it aims to answer are: Intrathecal nalbuphine as an adjuvant to local anesthetic will better provide pain relief after TURP surgery. Participants will be given a combination of nalbuphine and local anesthetic when getting a spinal block. Researchers will compare control group, given look-alike solution that contains no active drug to see if nalbuphine will better provide pain relief after surgery.

Detailed description

This study aims to evaluate the efficacy and side effects of nalbuphine, with the goal of providing anesthesiologists with evidence-based guidance for selecting the most appropriate pharmacological agents for their patients. Participants will be given a combination of nalbuphine and local anesthetic when getting a spinal block. Researchers will compare control group, given look-alike solution that contains no active drug to see if nalbuphine will better provide pain relief after surgery.

Conditions

• Transurethral Resection of Prostate

Interventions

Type	Name	Description
DRUG	Nalbuphine Hydrochloride 10 MG/ML	Nalbuphine(10mg/ml) 0.8 mg intrathecal
DRUG	Sodium Chloride 0.9 % in 5 ML Injection	0.9% Sodium Chloride 0.08 ml intrathecal
DRUG	Bupivacaine Hydrochloride, Spinal	0.5% Hyperbaric or Isobaric Spinal Bupivacaine 1-4 ml intrathecal
DRUG	Nalbuphine Hcl 10Mg/Ml Inj	4 mg IV prn for postoperative pain score\>=4 q 6 h
DRUG	Acetaminophen 500Mg Tab	1 tab oral prn for postoperative pain score 1-3 q 6 h
DRUG	Ondansetron 8mg	8 mg IV prn for nausea or vomiting q 8 h

Timeline

• Start date: 2023-12-07
• Primary completion: 2024-11-27
• Completion: 2024-11-28
• First posted: 2023-12-01
• Last updated: 2025-01-13

Locations

1 site across 1 country: Thailand