NCT06152575

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 492 (estimated)
• Sponsor: Pfizer · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years of age or older and have MM. * Have received treatments before for MM. * Have MM that has returned or not responded to their most recent treatment. Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM. Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study. The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as: * a shot under the skin at the study clinic * through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects. Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits). The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.

Conditions

• Multiple Myeloma

Interventions

Type	Name	Description
DRUG	Elranatamab	Elranatamab will be administered subcutaneously
DRUG	Elotuzumab	Elotuzumab will be administered intravenously
DRUG	Pomalidomide	Pomalidomide will be administered orally
DRUG	Dexamethasone	Dexamethasone will be administered orally
DRUG	Bortezomib	Bortezomib will be administered subcutaneously or intravenously
DRUG	Carfilzomib	Carfilzomib will be administered intravenously

Timeline

• Start date: 2024-02-08
• Primary completion: 2026-08-30
• Completion: 2027-12-30
• First posted: 2023-11-30
• Last updated: 2026-04-16

Locations

274 sites across 27 countries: United States, Argentina, Australia, Belgium, Brazil, Canada, Chile, Croatia, Czechia, Denmark, Finland, France, Germany, Greece, Israel, Italy, Japan, Netherlands, Norway, Portugal, Slovakia, Slovenia, South Korea, Spain, Sweden, Taiwan, United Kingdom

Regulatory

• FDA-regulated drug study