NCT06148662

The Effect of Oral Sprays on Salivary pH

The Effect of Oral Sprays on Salivary pH Changes After Coca-cola Consumption

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: I.M. Sechenov First Moscow State Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 44 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to assess the effect of oral foams on salivary pH changes after Coca-cola consumption in young adults.

Detailed description

This will be a cross-over clinical trial assessing the effect of oral foams containing zink hydroxiapatite and probiotics (Lactobacillus, Bifidobacterium), Olaflur (amino fluoride), and oral spray with alkaline thermal water. The study will be conducted in six visits over a period of 1.5 months. After enrolment, dental examination will be performed using the following indices: DMFT, OHI-S index, Bleeding index. Saliva buffer capacity, salivary flow rate, and baseline salivary pH will be measured. Salivary pH changes will be registered after consumption of Coca-cola alone or followed by each of the tested products application.

Conditions

• Oral Health

Interventions

Type	Name	Description
OTHER	No intervention (negative control)	The participants will be asked to hold 20 ml of "coca-cola" in their mouth for 30 seconds.
OTHER	Water (positive control)	The participants will be asked to hold 20 ml of "coca-cola" in their mouth for 30 seconds. Then, participants will to rinse their mouth with tap water 60 seconds.
DRUG	Dental foam "Biorepair PERIBIOMA"	The participants will be asked to hold 20 ml of "coca-cola" in their mouth for 30 seconds. Then, participants will use a dental foam "Biorepair PERIBIOMA" to rinse their mouth. They should rinse their mouth for 60 seconds and then spit out the foam.
DRUG	Dental foam "WATER:DENT"	The participants will be asked to hold 20 ml of "coca-cola" in their mouth for 30 seconds. Then, participants will use a dental foam "WATER:DENT" to rinse their mouth. They should rinse their mouth for 60 seconds and then spit out the foam.
DRUG	Dental spray "BUCCOTHERM"	The participants will be asked to hold 20 ml of "coca-cola" in their mouth for 30 seconds. Then, participants will use a dental spray "BUCCOTHERM" to rinse their mouth. They should rinse their mouth for 60 seconds and then spit out the foam.

Timeline

• Start date: 2023-12-01
• Primary completion: 2024-01-25
• Completion: 2024-01-25
• First posted: 2023-11-28
• Last updated: 2024-03-05

Locations

1 site across 1 country: Russia