NCT06145191

Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy

Prophylactic Tranexamic Acid Versus Adrenaline for Bleeding Prevention During Flexible Bronchoscopy: a Double Blind, Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,013 (actual)
• Sponsor: Clinical Hospital Centre Zagreb · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Endobronchial bleeding is a common complication of bronchoscopy. Major bleeding, although rare, can be life threatening and often requires advanced therapeutic interventional pulmonary procedures which are not widely available. Minor bleeding can negatively impact outcomes such as diagnostic yield, sample size and bronchoscopy duration. Both adrenaline and tranexamic acid are successfully used topically for hemostasis during diagnostic bronchoscopy. The aim of this study is to evaluate the efficacy of prophylactically applied adrenaline and tranexamic acid in bleeding prevention during diagnostic bronchoscopy.

Conditions

• Bleeding
• Hemoptysis

Interventions

Type	Name	Description
DRUG	Tranexamic acid	Prophylactic topical application (1x) of tranexamic acid (100mg, 2ml, room temperature) before sampling
DRUG	Adrenaline	Prophylactic topical application (1x) of adrenaline (1:10.000, 2ml, room temperature) before sampling
DRUG	Placebo	Prophylactic topical application (1x) of placebo (0.9% NaCl, 2ml, room temperature) applied before sampling

Timeline

• Start date: 2023-12-18
• Primary completion: 2025-03-28
• Completion: 2025-03-28
• First posted: 2023-11-24
• Last updated: 2025-08-01

Locations

1 site across 1 country: Croatia