NCT06143943

Anterior Segment Anatomic Parameters for Risk Profiling of Primary Angle-closure Glaucoma

Anterior Segment Anatomic Parameters Based on the Scleral Spur and Cornea for Risk Profiling of Primary Angle-closure Glaucoma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 168 (actual)
• Sponsor: Min Ke · Academic / Other
• Sex: All
• Age: 30 Years – 92 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to examine the anterior segment anatomical parameters associated with the scleral spur and cornea for risk profiling of primary angle-closure glaucoma (PACG). The main question it aims to answer is: • Are there new anatomical parameters of the anterior segment of the eye that can be used early for risk profiling for PACG? Researchers will compare PACG and narrow angle groups to see if there are some anatomical parameters that can distinguish the two.

Detailed description

We aimed to examine the anterior segment anatomical parameters associated with the scleral spur and cornea for risk profiling of primary angle-closure glaucoma (PACG). This retrospective study included 84 patients with PACG and 84 patients with narrow angles (NA). We collected parametric measurements obtained using anterior-segment optical coherence tomography and IOLMaster 700. Univariate and multivariate logistic regression models were used to compare the ocular parameters between the NA and PACG groups as well as to identify risk factors for PACG. The predictive performance of each parameter was evaluated using the area under the receiver operating characteristic curve (AUROC) analysis.

Conditions

• Glaucoma, Angle-Closure

Timeline

• Start date: 2022-11-22
• Primary completion: 2022-12-31
• Completion: 2023-02-28
• First posted: 2023-11-22
• Last updated: 2023-11-22

Locations

1 site across 1 country: China