NCT06143410

Intravenous Lidocaine to Reduce ED50 for Propofol Administered Using Target Controlled Infusion (TCI) During Gastroscopy

Does Intravenous Lidocaine Reduce ED 50 for Propofol Administered Using Target Controlled Infusion (TCI) During Gastroscopy in ASA 1 and 2 Patients.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Erasme University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this prospective, interventionnal clinical trial is to assess if intravenous administration of linisol reduce the ED50 of propofol when administered using Target Controlled Infusion (TCI) during gastroscopy in healthy patients (ASA 1 and 2 patients). Prior to propofol sedation, participants will receive either an intravenous bolus of linisol (1.5 mg/kg) = treated group or placebo = control group.

Conditions

• Diagnostic Gastroscopy

Interventions

Type	Name	Description
DRUG	Lidocaine 2% Injectable Solution	administration of a bolus of lidocaine 1.5 mg/kg
DRUG	Saline administration as placebo	administration of a bolus of saline solution as a placebo
DRUG	Propofol injection	Sedation by total intravenous administration (TIVA) of propofol using target controlled infusion (TCI)
PROCEDURE	gastroscopy	esogastroduodenoscopy

Timeline

• Start date: 2024-04-08
• Primary completion: 2024-08-31
• Completion: 2024-08-31
• First posted: 2023-11-22
• Last updated: 2024-04-24

Locations

1 site across 1 country: Belgium