NCT06142565

Treatment of Postviral Olfactory Dysfunction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

A decreased sense of smell (hyposmia) is often caused by viral infections, such as COVID-19. Today, the only recommended treatment for hyposmia is olfactory training, a time consuming method with limitations in terms of both compliance and effect. The aim of this study is therefore to evaluate, as well as optimize, a new treatment method for olfactory loss. Hyposmic participants will be recruited and randomized into two different treatment conditions. One group will do regular olfactory training and the other will do passive olfactory training with scented nose plugs. The training will be conducted in the home of the individual monday through friday for two consecutive months. Subjective and objectvie measures of olfactory problems will be assessed before and after treatment, as well as subjective measures related to quality of live and genereal wellbeing.

Conditions

• Hyposmia

Interventions

Type	Name	Description
DEVICE	Nose plug	Participants will complete olfactory training with scented nose plugs.
OTHER	Regular olfactory training	Participants will complete olfactory training with regular odors found in their home.

Timeline

• Start date: 2023-10-17
• Primary completion: 2024-06-21
• Completion: 2025-07-01
• First posted: 2023-11-21
• Last updated: 2025-09-03

Locations

1 site across 1 country: Sweden