NCT06142136

The Effect of Vitamin D Sublingual Spray on Vitamin D3 Levels in the Blood Compared to Other Forms of Vitamin D3

A Randomised Comparative Study of the Effect of LYL Love Your Life ® sunD3 LYL Micro™ Vitamin D Sublingual Spray on Vitamin D3 Levels in the Blood Compared to Other Forms of Vitamin D3 - Oral Oil Droplets and Capsules

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 99 (actual)
• Sponsor: Pauls Stradins Clinical University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The randomized comparative study was performed on 99 outpatients with below 30 ng/ml of vitamin D. Participants were randomized into three groups to receive vitamin D3 supplementation in three different forms - sublingual spray, oral oil droplets, and capsules. Each participant received vitamin D3 4000 IU daily for 30 days and the vitamin D levels were measured before and after the intervention.

Detailed description

This randomized comparative study was performed in Liepaja, Latvia, on 99 outpatients, with vitamin D levels below 30 ng/ml. Participants were randomized into three groups to receive vitamin D3 supplementation in three different forms - sublingual spray, oral oil droplets, and capsules. Before intervention blood samples were taken to determine vitamin D3 level, creatinine, and GFR, each participant received vitamin D3 4000 IU daily for 30 days. After that blood test was performed again, to measure changes in vitamin D3 levels in the blood. Participants answered the questionnaire to collect information about things that might affect vitamin D3 levels, such as dietary habits, physical activities, usage of sunscreen, compliance, etc.

Conditions

• Vitamin D3 Deficiency

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin D substitution with sublingual sprayable microemulsion.	Participants received sublingual sprayable microemulsion of vitamin D3 4000 IU daily for 30 days.
DIETARY_SUPPLEMENT	Vitamin D substitution with oil droplets	Participants received oil droplets of vitamin D3 4000 IU daily for 30 days.
DIETARY_SUPPLEMENT	Vitamin D substitution with capsules	Participants received capsules of vitamin D3 4000 IU daily for 30 days.

Timeline

• Start date: 2021-03-28
• Primary completion: 2021-04-26
• Completion: 2021-04-26
• First posted: 2023-11-21
• Last updated: 2023-11-21

Locations

1 site across 1 country: Latvia