NCT06141213

The Relationship Between Fetal Membrane Thickness and Fetal Chromosomal Aneuploidies

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Tianjin Central Hospital of Gynecology Obstetrics · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This observational study aims to recruit pregnant women between 18 to 24 weeks of gestation to investigate the relationship between amniotic membrane thickness and fetal chromosomal abnormalities. The primary objectives are to establish whether a correlation exists between the measured thickness of the amniotic membrane and the presence of chromosomal abnormalities in the fetus, and to determine a cutoff value for amniotic membrane thickness that could indicate an increased risk of such abnormalities. Additionally, the study seeks to assess whether the inclusion of amniotic membrane thickness as a biomarker can enhance the detection rate of non-invasive prenatal testing (NIPT) and nuchal translucency (NT) for chromosomal abnormalities.

Conditions

• Chromosome Aberrations

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Ultrasound screening	Ultrasound screening for fetal membrane thickness at 18-24 weeks of pregnancy.

Timeline

• Start date: 2021-10-01
• Primary completion: 2023-12-31
• Completion: 2024-08-31
• First posted: 2023-11-21
• Last updated: 2023-11-21

Locations

1 site across 1 country: China