NCT06135870

Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)

Role of Senescent Cells in Uterine Fibroid Pathogenesis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: Female
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The investigators are evaluating the role of senescent cells in uterine fibroids.

Detailed description

Uterine fibroids are prevalent tumors of uterus characterized by excessive fibrotic tissues. Using new cutting-edge computational methods, the investigators have found that small groups of senescent cells in fibroids work in concert with immune cells to produce soluble factors in fibroid tissues to create a feed-forward loop leading to fibrosis. This project seeks to unravel key cell-cell communication networks involving senescent and immune cells in fibroids to develop new treatments for uterine fibroids.

Conditions

• Fibroid
• Leiomyoma

Timeline

• Start date: 2023-11-01
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2023-11-18
• Last updated: 2025-12-11

Locations

1 site across 1 country: United States