NCT06135597

Immune Regulation in Chronic Aspergillus Infection After COVID-19 Infection

Role of Cellular Immune Regulation in Acute Exacerbation and Chronic Aspergillus Infection After COVID-19 Infection

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Taipei Veterans General Hospital, Taiwan · Other Government
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

This study aims to collect clinical cases and follow-up data from patients with chronic pulmonary aspergillosis, post-COVID-19 aspergillosis, and post-COVID-19 patients without aspergillosis. Using in vitro assays, we will measure the phagocytic function of neutrophils when stimulated by fungal hyphae, their ability to produce neutrophil extracellular traps (NETs), the expression of cell surface molecules at the time of enrollment, changes in cell surface molecule expression after stimulation with fungal hyphae, and the quantification of autoantibodies in the blood. This research will focus on the short-term (within 3 months), medium-term (6-12 months), and long-term (more than 12 months) changes in cell surface molecules and functions following infection.

Conditions

• Aspergillosis

Interventions

Type	Name	Description
OTHER	This is a blood test without regarding to intervention nor diagnostic tests	This is a blood test without regarding to intervention nor diagnostic tests

Timeline

• Start date: 2023-03-23
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2023-11-18
• Last updated: 2023-11-18

Locations

1 site across 1 country: Taiwan