NCT06133127

Is There an Association Between Quadriceps Strength and Different Markers of Fragility in Patients With Cirrhosis?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: University Hospital, Clermont-Ferrand · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Physical frailty and malnutrition are important factors in morbidity and mortality in patients with cirrhosis. No study has assessed the validity of Liver Frailty Index (LFI) against reference measures such as maximal lower limb strength. Main objective: To assess the association between LFI score and isometric maximal lower limb strength (quadriceps) in patients with cirrhosis.

Detailed description

Secondary objective: compare the different strength parameters of patients with cirrhosis (strength endurance, rate of strength development) with healthy subjects.

Conditions

• Cirrhosis

Interventions

Type	Name	Description
OTHER	Frailty assessment	Assessments for all patients : isometric quadriceps strength, malnutrition by RFH-NPT and MNA questionnaires, body composition by circumference and triceps skinfold, frailty by LFI and SPPB, muscle cramps by Cramp questionnaire.
OTHER	Frailty assessments	Assessments for all healthy volunteers: isometric quadriceps strength, body composition by circumference and triceps skinfold, frailty by LFI and SPPB.

Timeline

• Start date: 2023-11-20
• Primary completion: 2026-03-26
• Completion: 2026-03-26
• First posted: 2023-11-15
• Last updated: 2026-04-06

Locations

1 site across 1 country: France