NCT06127667

Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 102 (estimated)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 21 Years – 95 Years
• Healthy volunteers: Accepted

Summary

This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules. This study is not masked and its primary purpose is to develop a basic science understanding of the relationship between cerebrovascular health and balance control with aging. This study will involve 102 individuals classified as younger adults, middle-aged adults, and older adults who are neurotypical and cognitively normal. The primary outcome from a clinical trials perspective will be cerebrovascular response to a bout of aerobic exercise (i.e. change in cerebral blood flow with the performance of aerobic exercise on a recumbent stepper exercise machine). Non-interventional outcomes will be EEG measures of cortical activity and biomechanical kinetic and kinematic data recorded during standing balance reactions, as well as biological blood samples for genomic analysis.

Conditions

• Neurotypical
• Cognitively Normal

Interventions

Type	Name	Description
BEHAVIORAL	aerobic exercise	use of single bout of aerobic exercise

Timeline

• Start date: 2024-10-15
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2023-11-13
• Last updated: 2026-03-27

Locations

1 site across 1 country: United States