NCT06122155

Effects of Posterior Parietal Cortex and Cerebellum Anodal tDCS on Ankle Tracking Visuomotor Adaptation

Investigating How Cortical Modulation of the Cerebellum and Posterior Parietal Cortex Using Anodal tDCS Influences Ankle Motor Adaptation After Motor Learning

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 29 Years
• Healthy volunteers: Accepted

Summary

Motor adaptation is guided by state estimation, a dynamic prediction of the interaction consequences between body and environment in the sensorimotor system. Previous studies have shown that the posterior parietal cortex (PPC) and cerebellum are potential candidates for state estimators. However, neither direct evidence linking neural substrates of state estimation and motor adaptation nor the differences in state estimation in these two brain areas was presented. A comparison of neuromodulation effects over PPC and cerebellum in motor adaptation tasks could provide direct evidence to solve the knowledge gap. Objective: This study aims to provide direct evidence to link state estimation and motor adaptation, and the neuromodulation effects of PPC and cerebellum in motor adaptation by using anodal transcranial direct current stimulation.

Detailed description

This was a single-blind, sham-controlled study. All participants were randomized to the PPC, cerebellum, and sham stimulation group. The ankle tracking system was used to record the ankle tracking visuomotor task during the motor learning phase, motor adaptation phase, and motor re-adaptation phase. Normalized root-mean squared error (RMSE) and RMSE reduction rate were measured as the performance outcome. A 20-minute atDCS at 2 mA anodal tDCS was given during the motor adaptation phase. The immediate effect and after effect of tDCS were seen in the motor adaptation phase and motor re-adaptation phase, respectively.

Conditions

• Transcranial Direct Current Stimulation

Interventions

Type	Name	Description
DEVICE	Transcranial direct current stimulation (Anodal)	20-minutes, 2 mA anodal tDCS delivering through two 5 cm x 7 cm electrodes
DEVICE	Transcranial direct current stimulation (Sham)	20-minutes, 0 mA anodal tDCS delivering through two 5 cm x 7 cm electrodes

Timeline

• Start date: 2022-11-26
• Primary completion: 2023-06-19
• Completion: 2023-06-19
• First posted: 2023-11-08
• Last updated: 2023-11-14

Locations

1 site across 1 country: Taiwan