NCT06114888

Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: Novel Diagnostics

Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: a Feasibility Randomized Controlled Trial of a Diagnostic Intervention

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Jeffrey · Academic / Other
• Sex: All
• Age: 6 Months – 18 Years
• Healthy volunteers: Not accepted

Summary

Children are commonly hospitalized because of community-acquired pneumonia. Despite the fact that many of these children have viral disease, a majority is treated with antibiotics. These antibiotics will not accelerate recovery in those with viral pneumonia and can cause harm. We are interested in exploring whether the MeMed BV - a composite biomarker assay - could be used to improve antibiotic prescribing in these children by identifying those who likely have viral disease. This proposal describes a feasibility randomized trial of this diagnostic intervention.

Conditions

• Community-acquired Pneumonia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MeMed BV + Usual Care	We will aim to have blood drawn for MeMed BV testing within 24 hours of the first dose of IV antibiotics. We will then aim to have test results back within 24 hours of sampling.
OTHER	Usual Care Alone	Usual care can involve oxygenation support, ventilatory support, intravenous fluids, and antibiotics, or any combination of these.

Timeline

• Start date: 2024-04-17
• Primary completion: 2025-11-30
• Completion: 2026-01-01
• First posted: 2023-11-02
• Last updated: 2024-12-10

Locations

1 site across 1 country: Canada