NCT06111261

Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance

Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance: A Randomized Controlled Trial (ABSOLUTE Trial)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This study is designed to evaluate the effect of early albumin transfusion within massive transfusion protocol on fluid balance and reduced requirement of transfusion.

Detailed description

Eligible patients who require massive transfusion will be randomized in a single-blind manner (participant) in a 1:1 ratio to Conventional Massive Transfusion Pro. tocol group (C-MTP) or Albumin Massive Transfusion Protocol group (A-MTP). When MTP is initiated according to the result of randomization, all patients(or a legal guardian) are informed about the study and potential risks and benefits. Study will be continued only in patients who give informed consent.

Conditions

• Bleeding
• Massive Hemorrhage
• Massive Transfusion Protocol

Interventions

Type	Name	Description
DRUG	Albumin solution	200ml of 20% Human Serum Albumin
DRUG	Balanced crystalloid solution	Balanced crystalloid solution

Timeline

• Start date: 2023-11-15
• Primary completion: 2025-07-15
• Completion: 2025-08-15
• First posted: 2023-11-01
• Last updated: 2023-11-01