NCT06108362

Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients

Effect of Intraoperative Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients: a Randomized, Double-blind, Placebo-controlled Study

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 104 (estimated)
• Sponsor: Beijing Tsinghua Chang Gung Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate the effect of intraoperative terlipressin on the incidence of early postoperative acute kidney injury in deceased doner liver transplantation. Patients were randomly divided into experimental group and control group by numerical randomization table. The experimental group was injected with terlipressin perioperative and the control group was injected with placebo

Detailed description

acute kidney injury is a relatively common complication in patients with liver transplantation. Most centers have established prediction models for acute kidney injury after liver transplantation, but the incidence cannot be reduced through perioperative anesthesia management. As an vasopressin receptor agonist, terlipressin can increase blood pressure and improve kidney perfusion at the same time, and perioperative application may reduce the incidence of postoperative acute kidney injury

Conditions

• Acute Kidney Injury
• Liver Transplant; Complications

Interventions

Type	Name	Description
DRUG	Terlipressin	The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins
DRUG	normal saline	The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins

Timeline

• Start date: 2023-08-18
• Primary completion: 2024-06-30
• Completion: 2024-06-30
• First posted: 2023-10-31
• Last updated: 2023-10-31

Locations

1 site across 1 country: China