NCT06103981

Acute Liver Injury in Patients With Pneumonia

Acute Liver Injury in Patients With Pneumonia and Its Impact on Hospital Stay and Outcome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 176 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 68 Years
• Healthy volunteers: Not accepted

Summary

Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease. A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy

Detailed description

Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII . Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life. In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern. There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.

Conditions

• Acute Liver Injury
• Pneumonia

Interventions

Type	Name	Description
OTHER	Acute Liver Injury	To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.

Timeline

• Start date: 2023-12-01
• Primary completion: 2025-01-10
• Completion: 2025-03-10
• First posted: 2023-10-27
• Last updated: 2023-10-27

Locations

1 site across 1 country: Egypt