NCT06102590

Oxygen Extraction-guided Transfusion

Oxygen Extraction-guided Transfusion Strategy in Critically Ill Patients. A Randomized Controlled Trial.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 324 (estimated)
• Sponsor: Università degli Studi di Ferrara · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT (i.e., hemoglonim level \< 7.0 g/dL).In our previous study, oxygen extraction ratio (O2ER) has shown good performance as a marker to identify the correct timing for RBCT, potentially affecting 90-day mortality in non-bleeding, critically ill patients \[11\]. Moreover, our data suggested that an individualized strategy for RBCT may reduce the incidence of acute kidney injury (AKI), which is possibly related to a better delivery of oxygen and organ perfusion.

Conditions

• Blood Transfusion

Interventions

Type	Name	Description
OTHER	Individualized red blood cell transfusion strategy	Prescription of RCBT is restricted to patients who present Hb ≤ 9.0 g/dL and O2ER ≥ 30%.
OTHER	European guidelines red blood cell transfusion strategy	RBCT according to ESICM guidelines

Timeline

• Start date: 2023-11-04
• Primary completion: 2026-11-01
• Completion: 2027-01-01
• First posted: 2023-10-26
• Last updated: 2025-07-31

Locations

4 sites across 2 countries: Belgium, Italy