Trials / Unknown
UnknownNCT06101758
Ultrasound Assessment of Sarcopenia in Patients With Chronic Liver Disease: the SARCOLIVER Study
Prospective Study of Ultrasound Assessment of Sarcopenia and Correlated Clinical Outcomes in Patients With Chronic Liver Disease: the SARCOLIVER Study
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 125 (estimated)
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
- Sex
- All
- Age
- 18 Years – 69 Years
- Healthy volunteers
- Not accepted
Summary
Sarcopenia is a complex multifactorial syndrome which could be present in older age (primary sarcopenia) or earlier in chronic disease (secondary sarcopenia). Even if in patients with chronic liver disease an association among sarcopenia and poor clinical outcomes is well known, the data available about the prevalence of sarcopenia in patients with liver cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma are very variable according to the populations in object and, furthermore, few data are available regarding the use of muscular ultrasound to detect this condition. The aim of this study is to define the prevalence of sarcopenia in patients with liver cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma in follow-up at our center and the clinical outcomes associated with this condition, and to determine the reliability of muscular ultrasound to diagnose the condition of sarcopenia through a comparison with other validated techniques such as computed tomography, magnetic resonance imaging and dual-energy X-ray absorptiometry.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Handgrip strength test | A handgrip strength test using a hydraulic hand dynamometer will be performed |
| DIAGNOSTIC_TEST | total body Dual Energy X-Ray Absorptiometry (DXA) | A total body Dual Energy X-Ray Absorptiometry (DXA) to estimate muscle mass will be performed |
| DIAGNOSTIC_TEST | Muscle ultrasound | A muscular ultrasound of abdominal muscles, forearm muscles, quadriceps and gastrocnemius will be performed |
Timeline
- Start date
- 2023-10-20
- Primary completion
- 2024-07-01
- Completion
- 2025-07-01
- First posted
- 2023-10-26
- Last updated
- 2023-10-26
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06101758. Inclusion in this directory is not an endorsement.