NCT06092853

Inflammatory Stress and Periodontal Tissue Destruction

Inflammatory Stress and Periodontal Tissue Destruction in Patients With Metabolic Syndrome and Periodontitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Recep Tayyip Erdogan University Training and Research Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Metabolic syndrome and periodontitis are diseases that lower the quality of life and their incidence rates are increasing. Since both of these diseases are associated with systemic inflammation and insulin resistance, they may be comorbid. The aim of this study was to evaluate the effect of interleukin-20 (IL-20) on periodontal destruction in individuals with metabolic syndrome while considering the relationship between metabolic syndrome and periodontitis. This study included a total of 80 individuals who were systemically and periodontally healthy (CG, n=20), were systemically healthy and had periodontitis (PG, n=20), had metabolic syndrome and were periodontally healthy (MG, n=20), or had both metabolic syndrome and periodontitis (MPG, n=20). Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses.

Conditions

• Oxidative Stress
• Inflammation

Interventions

Type	Name	Description
OTHER	Gingival crevicular fluid (GCF) and serum samples	Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Timeline

• Start date: 2022-06-06
• Primary completion: 2023-03-06
• Completion: 2023-06-06
• First posted: 2023-10-23
• Last updated: 2023-10-23

Locations

1 site across 1 country: Turkey (Türkiye)