NCT06091553

Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy

Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy: A Randomized Controlled Trial

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to elucidate the relationship between the Efficacy and Safety of Comparison of the Efficacy and Safety Duloxetine augmented with gabapentin and amitriptyline augmented with Duloxetine vs duloxetine alone in chemotherapy -Induced Neuropathy in cancer patients.

Conditions

• Neuropathy in Cacer Patien

Interventions

Type	Name	Description
DRUG	Duloxetine alone	30 mg once daily for 1 week, then 60 mg once daily
DRUG	Duloxetine augmented with gabapentin	30 mg once daily for 1 week, then 60 mg once daily 300 mg at bedtime
DRUG	Duloxetine augmented with amitriptyline (as combined therapy)	10 to 25 mg once daily at bedtime 30 mg once daily for 1 week, then 60 mg once daily

Timeline

• Start date: 2023-10-10
• Primary completion: 2024-09-30
• Completion: 2024-12-31
• First posted: 2023-10-19
• Last updated: 2024-04-16

Locations

1 site across 1 country: Egypt